The files "c.py", "cpp.py", and "cconfig.py" in "interscript/compilers/" are set up for my Linux box, and invoke "gcc" and "g++" with appropriate options for building python modules and command line executables. You may need to modify (or even rewrite) these modules to make them work at your site.
These modules are not required by interscript, but they're generally nice to have, and they will be used by me when distributing C or C++ code hosted by interscript (instead of makefiles).
These files are generated by interscript from the source "interscript/src/compilers.ipk".